Ubiquitin K63 Heavy


  • Description

  • Application Data


Sequence corresponding to the bond between Lys63 side-chain linked mammalian ubiquitin proteins. Contains arginine residue labelled with 13C and 15N isotopes

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Application Data

Catalogue number crb1300818
Molecular Weight 2253.2
Sequence (one letter code)


Sequence (three letter code)


Purity >95%
Storage -20°C

Heunis et al., (2020). Technical report: Targeted proteomic analysis reveals enrichment of atypical ubiquitin chains in contractile murine tissues. Journ. Prot. Res., 229: 103963. doi: 10.1016/j.jprot.2020.103963.


Ohtake et al (2018) K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains. PNAS 115(7) E1401 PMID: 29378950

Swatek and Komander (2016) Ubiquitin modifications. Cell Res. 26(4) 399 PMID: 27012465

Holzer et al (2012) Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis. Neuropeptides 46(6) 261 PMID: 22979996

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

This sequence corresponds to the peptide bond between mammalian Lys63- (K63) linked Ub proteins; where (GG) corresponds to the C-terminus of the side chain appended Ub.

K63-linked chains are the second most abundant linkage types found in cells and are modified with Met1-linked chains in mixed or branched architectures. K63-linked chains have a variety of non-degradative roles including; roles in intracellular trafficking, kinase signalling, DNA damage response, inflammatory signalling and NF-κB activation, however they may also be involved in some proteosome dependent pathways

The N-terminal arginine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide.

Ubiquitin K63 Heavy

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