Ubiquitin K29 Heavy

A-[K(GG)]-IQD-[U-13C6 15N2-Lys]-acid

  • Description

  • Application Data


Sequence corresponding to the bond between Lys29 side-chain linked mammalian ubiquitin proteins. Contains lysine residue labelled with 13C and 15N isotopes

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Application Data

Catalogue number crb1300812
Molecular Weight 823.5
Sequence (one letter code)

A-[K(GG)]-IQD-[U-13C6 15N2-Lys]-acid

Sequence (three letter code)

H-Ala-[Lys(Gly-Gly)]-Ile-Gln-Asp-[U-13C6 15N2-Lys]-OH

Purity >95%
Storage -20°C

Heunis et al., (2020). Technical report: Targeted proteomic analysis reveals enrichment of atypical ubiquitin chains in contractile murine tissues. Journ. Prot. Res., 229: 103963. doi: 10.1016/j.jprot.2020.103963.


Swatek, K. and Komander, D. (2016). Ubiquitin modifications. Cell Res, 26(4), 399-422. PMID: 27012465

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

This sequence corresponds to the peptide bond between mammalian Lys29- (K29) linked Ub proteins; where (GG) corresponds to the C-terminus of the side chain appended Ub.

K29-linked chains are assembled by the HECT E3 ligase KIAA10/UBE3C that assembles K29- and K48-linked polyubiquitin chains. K29-linked polyUbs are involved in growth and development-associated pathways (Wnt/β-catenin signalling), and are also implicated in regulation of mRNA stability and the epigenetic regulation and transcription of a set of interleukins (IL12 and IL23). In addition to this, K29-linked chains are also associated with the 26S proteasome, which suggests a role as a proteasomal degradation signal.

The C-terminal lysine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.

Ubiquitin K29 Heavy

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