Ubiquitin K27 Heavy

TITLEVEPSDTIENV-[K(GG)]-A-[U-13C6 15N2-Lys]-acid

  • Description

  • Application Data


Sequence corresponding to the bond between Lys27 side-chain linked mammalian ubiquitin proteins. Lysine residue labelled with 13C and 15N isotopes

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Application Data

Catalogue number crb1300810
Molecular Weight 2108.1
Sequence (one letter code)

TITLEVEPSDTIENV-[K(GG)]-A-[U-13C6 15N2-Lys]-acid

Sequence (three letter code)

H-Thr-Ile-Thr-Leu-Glu-Val-Glu-Pro-Ser-Asp-Thr-Ile-Glu-Asn-Val-[Lys-(Gly-Gly)]-Ala-[U-13C6 15N2-Lys]-OH

Purity >95%
Storage -20°C

Heunis et al., (2020). Technical report: Targeted proteomic analysis reveals enrichment of atypical ubiquitin chains in contractile murine tissues. Journ. Prot. Res., 229: 103963. doi: 10.1016/j.jprot.2020.103963.


Castañeda et al (2016) Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins. Structure 24(3) 423 PMID: 26876099

Swatek and Komander (2016) Ubiquitin modifications. Cell Res. 26(4) 399 PMID: 27012465

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

This sequence corresponds to the peptide bond between mammalian Lys27- (K27) linked Ub proteins; where (GG) corresponds to the C-terminus of the side chain appended Ub.

K27-linked chains are less well characterised than other Ub chains, however they have been suggested as a marker of mitochondrial damage and have also been implicated in regulation of innate immunity and DNA repair.

The C-terminal lysine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.

Ubiquitin K27 Heavy

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