Ubiquitin K27 Heavy
TITLEVEPSDTIENV-[K(GG)]-A-[U-13C6 15N2-Lys]-acid
Description
Application Data
Description
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Sequence corresponding to the bond between Lys27 side-chain linked mammalian ubiquitin proteins. Lysine residue labelled with 13C and 15N isotopes
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1300810 Molecular Weight 2108.1 Sequence (one letter code) TITLEVEPSDTIENV-[K(GG)]-A-[U-13C6 15N2-Lys]-acid
Sequence (three letter code) H-Thr-Ile-Thr-Leu-Glu-Val-Glu-Pro-Ser-Asp-Thr-Ile-Glu-Asn-Val-[Lys-(Gly-Gly)]-Ala-[U-13C6 15N2-Lys]-OH
Purity >95% Storage -20°C Citations Heunis et al., (2020). Technical report: Targeted proteomic analysis reveals enrichment of atypical ubiquitin chains in contractile murine tissues. Journ. Prot. Res., 229: 103963. doi: 10.1016/j.jprot.2020.103963.
References Castañeda et al (2016) Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins. Structure 24(3) 423 PMID: 26876099
Swatek and Komander (2016) Ubiquitin modifications. Cell Res. 26(4) 399 PMID: 27012465
Manufactured in: United Kingdom This sequence corresponds to the peptide bond between mammalian Lys27- (K27) linked Ub proteins; where (GG) corresponds to the C-terminus of the side chain appended Ub.
K27-linked chains are less well characterised than other Ub chains, however they have been suggested as a marker of mitochondrial damage and have also been implicated in regulation of innate immunity and DNA repair.
The C-terminal lysine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.
Ubiquitin K27 Heavy
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