Cathelicidin family anti-microbial peptide, broad spectrum activity against a range of microorganisms
Catalogue number crb1000021 Molecular Weight 1902.25 Sequence (one letter code) VRRFPWWWPFLRR-acid Sequence (three letter code) H-Val-Arg-Arg-Phe-Pro-Trp-Trp-Trp-Pro-Phe-Leu-Arg-Arg-OH Molecular Weight 1902.25 Purity >95% Storage - 20 ° C References
Cirioni et al., (2006). In Vitro Activities of Tritrpticin Alone and in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 50 (11), 3923. PMID: 16940073
Schibli et al., (2006). Structure-Function Analysis of Tritrpticin Analogs: Potential Relationships between Antimicrobial Activities, Model Membrane Interactions, and Their Micelle-Bound NMR Structures. Biophys J. 91 (12), 4413. PMID: 16997878
Sharma et al., (2013). Putative Bioactive Motif of Tritrpticin Revealed by an Antibody with Biological Receptor-Like Properties. PLoS One. 8 (9), e75582. PMID: 24086578
An anti-microbial peptide (AMP) of the cathelicidin family, originally discovered in pig neutrophils. Tritrpticin has potent and broad anti-microbial activity against Gram-positive and Gram-negative bacteria, some fungi, and protozoa.
Tritrpticin is thought to exist in a range of conformations in solution, and recognise its targets with high selectivity and efficiency whilst displaying low haemolytic activity. The peptides three sequential tryptophan residues flanked by two prolines and four arginines are important for the peptides interaction with membranes and for its mechanism of action. The presence of these three tryptophan and four arginines residues, also class Tritrpticin as a member of the Arg/Trp-rich family of AMPs.