Tritrpticin VRRFPWWWPFLRR-acid

  • Description

  • Application Data

Description

Cathelicidin family anti-microbial peptide, broad spectrum activity against a range of microorganisms

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Application Data

Catalogue number crb1000021
Molecular Weight 1902.25
Sequence (one letter code) VRRFPWWWPFLRR-acid
Sequence (three letter code) H-Val-Arg-Arg-Phe-Pro-Trp-Trp-Trp-Pro-Phe-Leu-Arg-Arg-OH
Molecular Weight 1902.25
Purity >95%
Storage - 20 ° C
References

Cirioni et al., (2006). In Vitro Activities of Tritrpticin Alone and in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 50 (11), 3923. PMID: 16940073

 

Schibli et al., (2006). Structure-Function Analysis of Tritrpticin Analogs: Potential Relationships between Antimicrobial Activities, Model Membrane Interactions, and Their Micelle-Bound NMR Structures. Biophys J. 91 (12), 4413. PMID: 16997878

 

Sharma et al., (2013). Putative Bioactive Motif of Tritrpticin Revealed by an Antibody with Biological Receptor-Like Properties. PLoS One. 8 (9), e75582. PMID: 24086578

Data Sheet Material Safety Data Sheet (MSDS)

An anti-microbial peptide (AMP) of the cathelicidin family, originally discovered in pig neutrophils. Tritrpticin has potent and broad anti-microbial activity against Gram-positive and Gram-negative bacteria, some fungi, and protozoa.

Tritrpticin is thought to exist in a range of conformations in solution, and recognise its targets with high selectivity and efficiency whilst displaying low haemolytic activity. The peptides three sequential tryptophan residues flanked by two prolines and four arginines are important for the peptides interaction with membranes and for its mechanism of action. The presence of these three tryptophan and four arginines residues, also class Tritrpticin as a member of the Arg/Trp-rich family of AMPs.

Tritrpticin

Cat No.Pack SizePriceQty.
1mg£110.00
0.5mg£85.00
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