Thyroglobulin (Tg-VIF) Heavy

VIFDANAPVAV-[U-13C6, U-15N4-Arg]-acid

  • Description

  • Application Data


Thyroglobulin (Tg-VIF) Heavy

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Application Data

Catalogue number crb1301707
Molecular Weight 1280.7
Sequence (one letter code)

VIFDANAPVAV-[U-13C6, U-15N4-Arg]-acid

Sequence (three letter code)

H-Val-Ile-Phe-Asp-Ala-Asn-Ala-Pro-Val-Ala-Val-[U-13C6, U-15N4-Arg]-OH

Purity >95%
Storage -20°C

Kushnir et al., (2013). Measurement of thyroglobulin by liquid chromatography-tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodies. Clin Chem., 59(6): 982. doi: 10.1373/clinchem.2012.195594.

Nishihara et al., (2022). Serum thyroglobulin evaluation on LC-MS/MS and immunoassay in TgAb-positive patients with papillary thyroid carcinoma. Eur. Thyroid J., 11: 1. Doi: 10.1530/ETJ-21-0041.

Data Sheet Material Safety Data Sheet (MSDS)

Serum levels of thyroglobulin (Tg) is considered a valuable measurement for quantitively evaluating thyroid cancer treatment efficacy. Immunoassays are commonly used for Tg level evaluation but return many false negatives. This is due to a large proportion of patients expressing anti-Tg antibodies (TgAb), which outcompete the reagent antibodies for Tg.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is potentially better at quantification of Tg as TgAb should less influence it.

The Tg-VIF heavy arginine residue at position 12 is isotopically labelled with carbon-13 and nitrogen-15. This will allow absolute quantification applications such as quantitative proteomics, the quantification of complex protein mixtures at very low concentrations, or NMR studies.

Thyroglobulin (Tg-VIF) Heavy

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