Tetanus Toxin P30 (947-967)
FNNFTVSFWLRVPKVSASHLE-acid
Description
Application Data
Description
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Tetanus Toxin P30 (947-967) is a protein that is derived from the single-chain polypeptide neurotoxin produced by Clostridium tetani.
Application Data
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Material Safety Data Sheet (MSDS)Catalogue number crb1001475 Molecular Weight 2477.3 Sequence (one letter code) FNNFTVSFWLRVPKVSASHLE-acid
Sequence (three letter code) H-Phe-Asn-Asn-Phe-Thr-Val-Ser-Phe-Trp-Leu-Arg-Val-Pro-Lys-Val-Ser-Ala-Ser-His-Leu-Glu-OH
Purity >95% Storage -20°C References Pellizzari et al (1999). Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses. Philos Trans R Soc Lond B Biol Sci. PMID: 10212474
Surana et al (2018). The travel diaries of tetanus and botulinum neurotoxins. Toxicon. PMID: 29031941
Manufactured in: United Kingdom Tetanus Toxin P30 (947-967) is a protein that is derived from the single-chain polypeptide neurotoxin produced by Clostridium tetani. The neurotoxins produced by Clostridium tetani are among the most potent molecules known to humankind. Once in the body, the toxin binds to the basal lamina at the neuromuscular junction. From here, the toxin is transported to inhibitory interneurons in the spinal cord, where it prevents the release of neurotransmitters, which causes spastic paralysis.