TAT-Beclin 1 YGRKKRRQRRRGGTNVFNATFEIWHDGEFGT-acid
TAT-Beclin 1 is a cell-penetrating peptide that induces autophagy through the interaction with the autophagy suppressor GAPR-1/GLIPR2. The TAT (48-60) is present to facilitate the movement of Beclin 1 across the plasma membrane. This peptide contains a GG linker between the C-terminus of TAT (47-57) and the N-terminus of Beclin 1.
Catalogue number crb1000910 Molecular Weight 3738.9 Sequence (one letter code) YGRKKRRQRRRGGTNVFNATFEIWHDGEFGT-acid Sequence (three letter code)
Purity >95% Storage -20°C References
Shoji-Kawata et al (2013) Identification of a candidate therapeutic autophagy-inducing peptide Nature 494 201 https://www.ncbi.nlm.nih.gov/pubmed/23364696
Kang et al (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell death and differentiation 18(4) 571 PMID: 21311563.
Manufactured in: United Kingdom
TAT-Beclin Scrambled is a peptide derived from a region of Beclin 1, which interacts with a newly identified negative regulator of autophagy, GAPR-1 (also called GLIPR2) to act as a potent inducer of autophagy. Autophagy is an essential process that maintains cellular homeostasis and carries out lysosome-mediated degradation of unwanted proteins in the cytoplasm. It is often examined when looking at disease pathways because of this regulatory function. While the immune system initiates the removal of viruses and pathogens through the autophagic pathway, some viruses (such as HIV) are able to evade this process.
TAT (47-57) is present due to its properties as a cell penetrating cationic peptide (CPP). It derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). As a CPP, TAT (47-57) is able facilitate the delivery of the Beclin scrambled protein across the plasma membrane.
This peptide contains a GG linker between the C-terminus of TAT (47-57) and the N-terminus of Beclin 1.