TAT-AKAP79 (326-336) amide

  • Description

  • Application Data

Description

Tat domain conjugated to the interacting domain of A-kinase anchoring protein 79 (AKAP79) with TRPV1, C-terminal acid.

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Application Data

Catalogue number crb1001279
Molecular Weight 2877.6
Disease Area Analgesia
Sequence (three letter code)

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Ser-Lys-Ser-Glu-Glu-Ser-Lys-Arg-Met-Glu-NH2

Storage -20°C
Citations

Btesh et al., (2013) Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia. J. Neurosci. 33(21): 9184. https://doi.org/10.1523/JNEUROSCI.4991-12.2013.

 

Du et al., (2019) The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System. Front. Physiol. 10: 1064. https://doi.org/10.3389/fphys.2019.01064.

References

Btesh et al., (2013) Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia. J. Neurosci. 33(21): 9184. https://doi.org/10.1523/JNEUROSCI.4991-12.2013.

 

Du et al., (2019) The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System. Front. Physiol. 10: 1064. https://doi.org/10.3389/fphys.2019.01064.

Material Safety Data Sheet (MSDS)

The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma, and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons, and the neurotransmitter anandamide.  The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.

 

This product is composed of the TRPV1 interacting residues of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain at the N-terminus. This product was shown in vivo to have a potent analgesic affect due to interaction with TRPV1 but not affect the pain threshold. This product is a vital tool for research into suitable TRPV1 antagonists.

TAT-AKAP79 (326-336) amide

Cat No.Pack SizePriceQty.
£110.00
£85.00
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