TAT (48-60) amide GRKKRRQRRRPPQ-amide
Description
Application Data
Description
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TAT (48-60) amide is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein found in the human immunodeficiency virus (HIV). This peptide has an uncharged C-terminal amide.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000173 Molecular Weight 1718.03 Sequence (one letter code) GRKKRRQRRRPPQ-amide Sequence (three letter code) H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-NH2
Purity >95% References Amani, J., Saffarian, P., Najar-Peerayeh, S., and Ali Imani- Fooladi, A. (2014). Designing and analyzing the structure of Tat-BoNT/A(1-448) fusion protein: An in silico approach. Molecular Biology Research Community, 3(2): 115–127. PMID: 30805378
Nancy M. Okuda-Shinagawa, Yulia E. Moskalenko, Helena C. Junqueira, Maurício S. Baptista, Carlos M. Marques, and M. Terêsa Machini. (2017). Fluorescent and Photosensitizing Conjugates of Cell-Penetrating Peptide TAT(47-57): Design, Microwave-Assisted Synthesis at 60 °C, and Properties. ACS Omega, 2(11): 8156–8166. PMID: 3002357
Manufactured in: United Kingdom TAT (48-60) amide is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). The 48-60 region of the TAT peptide is an arginine-rich bascic domain which as a whole has three domains that function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively.
This peptide has an uncharged C-terminal amide.