Spexin

NWTPQAMLYLKGAQ-amide

  • Description

  • Application Data

Description

Spexin is an endogenous neuropeptide with diverse roles in appetite, gastric motility, obesity, metabolism, mental health, and cardiovascular function.

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Application Data

Catalogue number crb1001435
Molecular Weight 1618.8
Sequence (one letter code)

NWTPQAMLYLKGAQ-amide

Sequence (three letter code)

H-Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH2

Aliase neuropeptide Q, NPQ
Purity >95%
cas 1370290-58-6
Storage -20°C
References

Kumar et al., (2021). Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease. Int J Obes, 45: 2169. doi: 10.1038/s41366-021-00906-2.

Lv et al., (2019). Emerging Roles of NPQ/Spexin in Physiology and Pathology. Front. Pharmacol., 10: 457. doi: 10.3389/fphar.2019.00457.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Spexin is a neuropeptide that is conserved amongst humans and rodents. Spexin activates galanin2/3 receptors, inducing a different active conformation of GalR2 to galanin. The broad distribution of spexin suggests multiple physiological roles including as a regulating factor in obesity and energy metabolism. Spexin is ubiquitously expressed in human tissue, however, a correlation has been found with obesity and age. Obese patients had significantly lower levels of circulating spexin than those with a healthy weight range. The significance of this suggests spexin regulates appetite, feeding behaviour, and energy expenditure. Spexin also specifically inhibits the uptake of long-chain fatty acids by adipocytes.

Spexin is a central modulator of cardiovascular and renal function and can elicit central nervous system behavioural responses. As spexin levels decrease with age there is research to understand if it plays a role in age-related pathophysiology of cardiometabolic conditions. Spexin is also being considered an early biomarker for cardiovascular disease due to the magnitude with which it decreases as the pathophysiology progresses.

Spexin

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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