• Description

  • Application Data


Spexin is an endogenous neuropeptide with diverse roles in appetite, gastric motility, obesity, metabolism, mental health, and cardiovascular function.

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Application Data

Catalogue number crb1001435
Molecular Weight 1618.8
Sequence (one letter code)


Sequence (three letter code)


Aliase neuropeptide Q, NPQ
Purity >95%
cas 1370290-58-6
Storage -20°C

Kumar et al., (2021). Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease. Int J Obes, 45: 2169. doi: 10.1038/s41366-021-00906-2.

Lv et al., (2019). Emerging Roles of NPQ/Spexin in Physiology and Pathology. Front. Pharmacol., 10: 457. doi: 10.3389/fphar.2019.00457.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Spexin is a neuropeptide that is conserved amongst humans and rodents. Spexin activates galanin2/3 receptors, inducing a different active conformation of GalR2 to galanin. The broad distribution of spexin suggests multiple physiological roles including as a regulating factor in obesity and energy metabolism. Spexin is ubiquitously expressed in human tissue, however, a correlation has been found with obesity and age. Obese patients had significantly lower levels of circulating spexin than those with a healthy weight range. The significance of this suggests spexin regulates appetite, feeding behaviour, and energy expenditure. Spexin also specifically inhibits the uptake of long-chain fatty acids by adipocytes.

Spexin is a central modulator of cardiovascular and renal function and can elicit central nervous system behavioural responses. As spexin levels decrease with age there is research to understand if it plays a role in age-related pathophysiology of cardiometabolic conditions. Spexin is also being considered an early biomarker for cardiovascular disease due to the magnitude with which it decreases as the pathophysiology progresses.


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