Spexin 2 (53-70) Human, Mouse, Rat


  • Description

  • Application Data


Spexin 2 (NPQ 53-70) fragment; spexin 2 contributes to central nervous system-mediated control of arterial blood pressure, salt and water balance, and modulates nociceptive responses.

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Application Data

Catalogue number crb1001598
Sequence (one letter code)



Toll et al., (2012). Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. FASEBJ, 26(2): 947. doi: 10.1096/fj.11-192831.

Wang et al., (2020). Characterization of a novel spexin gene (spx2) in the half-smooth tongue sole and regulation of its expression by nutritional status. Aquac. Rep., 18: 100544. doi: 10.1016/j.aqrep.2020.100544.

Material Safety Data Sheet (MSDS)

Spexin is a neuropeptide encoded by SPX genes, and homologs have been found amongst many vertebrates. The SPX genes encode a preprohormone that leads to the mature hormone spexin, which is highly conserved amongst higher vertebrates. Another form, SPX2, has been identified and named spexin 2. Both sequences of spexin and spexin 2 are highly conserved, suggesting they each play vital roles.

Like spexin, spexin 2 is widely expressed in various tissues. This is an amidated spexin-2 (53-70) peptide showing similar biological function to its non- amidated version. Spexin-2, when administered to rats, decreases heart rate and increases urine flow rate. Intraventricular NPQ(53-70) delivery also causes antinociceptive activity in mice’s warm water tail withdrawal assay.

Spexin 2 (53-70) Human, Mouse, Rat

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