Somatostatin 14 (human, rat, mouse, pig, chicken, frog)

AGCKNFFWKTFTSC-acid

  • Description

  • Application Data

Description

Somatostatin 14 is a peptide hormone which inhibits the release of several hormones with diverse functions. Contains a disulphide bridge between the cysteines residues at positions 3 and 14.

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Application Data

Catalogue number crb1001047
Molecular Weight 1636.7
Sequence (one letter code)

AGCKNFFWKTFTSC-acid

Sequence (three letter code)

H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH

Modifications disulphide bridge Cys3 - Cys14
Purity >95%
Storage -20°C
References

Anoop et al (2014) Elucidating the Role of Disulfide Bond on Amyloid Formation and Fibril Reversibility of Somatostatin-14. J. Biol. Chem. 289(24) 16884 PMID: 24782311

Stengel et al (2015) The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior. Horm. Behav. 73 15 PMID: 26026616

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Somatostatin-14 (SST-14) is a small cyclic peptide hormone secreted by hypothalamus. SST-14 has several roles including inhibiting the release of several hormones such as; growth hormone (GH), gastrin and gastric acid, insulin and glucagon and the regulation of amyloid beta-42. In the brain somatostatin increases body temperature and influences visceral functions (e.g. increased blood pressure, decreased heart rate, prevents sympathetically mediated hyperglycemia and stimulates gastric acid secretion).

Somatostatin is also present in an N-terminally extended form, somatostatin-28. In mammals, both somatostatin-14 and 28 originate from the prohormone, prosomatostatin, which is generated after removal of a 24 amino acid signal sequence from the 116 amino acids precursor, preprosomatostatin. Somatostatin-14 and 28 bind with similar affinity to five distinct somatostatin receptor subtypes, sst1 to sst5. These receptors belong to the G-protein coupled seven transmembrane domain receptor family and are related to the urotensin II receptors.

Somatostatin 14 (human, rat, mouse, pig, chicken, frog)

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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