Secretin (rat)

HSDGTFTSELSRLQDSARLQRLLQGLV-amide

  • Description

  • Application Data

Description

Secretin is a gastrointestinal hormone secreted by S cells in the small intestine, targeting G-protein coupled secretin receptors.

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Application Data

Catalogue number crb1000722
Molecular Weight 3025.6
Sequence (one letter code)

HSDGTFTSELSRLQDSARLQRLLQGLV-amide

Sequence (three letter code)

H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Gln-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2

Purity >95%
cas 121028-49-7
Storage -20°C
References

Afroze et al., (2013) The physiological roles of secretin and its receptor. Ann. Transl. Med. 1(3) 29 PMID: 25332973.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Secretin is a gastrointestinal hormone secreted by S cells in the small intestine, targeting G-protein coupled secretin receptors in numerous cell types. Secretin is synthesised from the preprohormone pro-secretin and is involved in regulating gastric acid and bicarbonate ion secretion in the duodenum and regulating water homeostasis. During glucose intake, secretin stimulates the pancreas to release insulin.

Secretin has clinical relevance as a method to detect gastrin-producing tumours. Administration of exogenous secretin to the duodenum for secretin stimulation test to occur. Secretin can also be used to detect pancreatic insufficiencies via s administration during endoscopic retrograde cholangiopancreatography (ERCP). This allows the detection of inflammatory and neoplastic conditions of the pancreas.

Secretin plays a different role in the central nervous system, such that in secretin deficient mice, synaptic plasticity and hippocampal synaptic activity are altered. Thus, secretin can be categorised as a neuropeptide.

Secretin (rat)

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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