SARS-CoV-2 Spike (1192-1200)
NLNESLIDL-acid
Description
Application Data
Description
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NLNESLIDL is an epitope from the SARS-CoV-2 spike protein (1192-1200). It is an epitope suitable for anti-viral targeting.
Application Data
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Data Sheet Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1001780 Molecular Weight 1029.5 Sequence (one letter code) NLNESLIDL-acid
Sequence (three letter code) H-Asn-Leu-Asn-Glu-Ser-Leu-Ile-Asp-Leu-OH
Purity >95% Storage -20°C References Jiang et al., (2022). SARS-CoV-2 Omicron Variant is Expected to Retain Most of the Spike Protein Specific Dominant T-Cell Epitopes Presented by COVID-19 Vaccines — Worldwide. China CDC Weekly, 4(18): 381. DOI: 10.46234/ccdcw2022.065.
Manufactured in: United Kingdom The SARS-CoV-2 spike protein is present on the outside of the virus particles and can bind to angiotensin-converting enzyme II (ACE2) present on the host cells. The C-terminal receptor binding domain (RBD) of the spike protein binds to the N-terminal peptidase M2 domain of ACE2. This receptor binding results in the internalisation of the virus-receptor complex and is, therefore the mechanism of entry of SARS-CoV-2 into host cells.
The spike protein residues NLNESLIDL (1192-1200) from SARS-CoV-2 have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.
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