SARS-CoV-2 ORF7a-10 (69-86)


  • Description

  • Application Data


The SARS-CoV-2 ORF7a-10 protein sequence DGVKHVYQLRARSVSPKL (69-86) has been identified as an epitope for anti-viral targeting.

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Application Data

Catalogue number crb1001840
Molecular Weight 2052.2
Sequence (one letter code)


Sequence (three letter code)


Purity >95%
Storage -20°C

Arshad et al., (2023). SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression. PNAS, 120(1): e2208525120. DOI: 10.1073/pnas.2208525120.

Manufactured in: United Kingdom
Data Sheet Data Sheet Material Safety Data Sheet (MSDS)

ORF7a is an accessory protein that is key to SARS-CoV-2 evading the immune system. ORF7a acts on the secretory pathway to lower surface MHC-I expression by specifically interacting with the MHC-I heavy chain and delaying its export from the endoplasmic reticulum. These factors make the ORF6 protein a viable target for developing new antiviral drugs. In addition, the identification of epitopes within the ORF7a-10 protein sequence can help design more effective SARS-CoV-2 vaccines.

Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. ORF7a-10 protein (69-86) is an epitope candidate with various predicted HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.

SARS-CoV-2 ORF7a-10 (69-86)

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