Relaxin 3 B1-22R amide
RAAPYGVRLSGREFIRAVIFTSR-amide
Description
Application Data
Description
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Relaxin-3 B1-22R amide is a relaxin-3 analogue; a valuable tool for studying the insulin/relaxin pathways.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1001188 Molecular Weight 2620.5 Sequence (one letter code) RAAPYGVRLSGREFIRAVIFTSR-amide
Sequence (three letter code) H-Arg-Ala-Ala-Pro-Tyr-Gly-Val-Arg-Leu-Ser-Gly-Arg-Glu-Phe-Ile-Arg-Ala-Val-Ile-Phe-Thr-Ser-Arg-NH2
Aliase R3 B1-22R Purity >95% Storage -20°C References Haugaard-Kedström et al., (2018). Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3. J Biol Chem., 293(41): 15765. PMID: 30131342.
Wong et al., (2018). Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor. JBC, 293(41): 15777. doi: 10.1074/jbc.RA118.002645.
Relaxin-3 is part of the insulin/relaxin superfamily with various roles, including appetite, stress, and addiction. Relaxin-3 binds to its cognate receptor relaxin family peptide 3 receptor (RXFP3). B1-22R is a single-chain relaxin-3 antagonist for RXFP3; no interaction is found with RXFP1 or RXFP4. B1-22R is a truncation of the B-chain of relaxin-3 and the addition of an arginine residue at the C-terminus; B1-22R acts as a RXFP3 antagonist. B1-22R has been used to perform structural analysis relationships (SARs) and residue scanning to understand the critical residues and conformation of the interaction between B1-22R and RXFP3. B1-22R can generate more potent analogs of relaxin-3 that are more stable and serve as models for drug design targeting the relaxin-3 receptor for regulation of addiction, stress, and appetite.
B1-22R is provided in the amide form. However, if you require an alternative version, please request a custom synthesis quotation by contacting crbsales@crbdiscovery.com.