Soybean trypsin inhibitor is an inhibitor for trypsin, plasmin, and plasma kallikrein
Catalogue number crb1100413 Molecular Weight 1130.6 Sequence (one letter code) (PFR)2-[Rh110] Sequence (three letter code) (Pro-Phe-Arg)2-[Rh110], Where 5-FAM is 5-carboxyfluorescein Aliase (PFR)2-[R110] Modifications Where 5-FAM is 5-carboxyfluorescein, where Rh110 is Rhodamine 110 Purity >95% References
Kalinska et al., (2016). Kallikreins - the melting pot of activity and function. Biochimie. 122: 270. PMID: 26408415
Manufactured in: United Kingdom
Soybean trypsin inhibitor inhibits trypsin, factor Xa, plasmin, and plasma kallikrein activity in serum-free cell culture media. It does not inhibit metallo-, cysteine, aspartic proteases, or tissue kallikrein (serine proteases).
Kallikreins (KLKs) are a large family of secreted serine proteases with either trypsin-like or chymotrypsin-like specificity which carry out many biological functions. The KLK proteases are involved in pathways that regulate skin desquamation, tooth enamel formation, kidney function, seminal liquefaction, synaptic neural plasticity, and brain function. Disruptions in the function of KLK activity has been linked to several pathologies, including respiratory diseases, neurodegeneration, anxiety, schizophrenia, skin-barrier dysfunction, pathological inflammation, and cancer.