Polybia-MPII
INWLKLGKMVIDAL-amide
Description
Application Data
Description
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Polybia-MPII is a mastoparan from the venom of the wasp Polybia paulista; a mild neurotoxin with myotoxic effects.
Application Data
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Data Sheet Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1001712 Molecular Weight 1612.0 Sequence (one letter code) INWLKLGKMVIDAL-amide
Sequence (three letter code) H-Ile-Asn-Trp-Leu-Lys-Leu-Gly-Lys-Met-Val-Ile-Asp-Ala-Leu-NH2
Purity >95% References Rocha et al., (2008). Mastoparan effects in skeletal muscle damage: An ultrastructural view until now concealed. MRT, 71(3): 220. doi: 10.1002/jemt.20542.
Rocha et al., (2009). The neurotoxicological effects of mastoparan Polybia-MPII at the murine neuromuscular junction: an ultrastructural and immunocytochemical study. Histochem Cell Biol 132, 395–404. doi: 10.1007/s00418-009-0607-z.
Silva et al., (2017). Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera). Int. J. Antimicrob., Agents 49(2): 167. doi: 10.1016/j.ijantimicag.2016.11.013.
Manufactured in: United Kingdom The crude venom of the wasp Polybia paulista consists of 30% polybia-MPII. Polybia-MPII is a mastoparan, it is rapidly distributed around the organism point of inoculation via the circulation. As a secretagogue, polybia-MPII has myotoxic action and minor neurotoxic effects. Polybia-MPII has been injected sub-cutaneously and intra-muscularly into mice for pathology and immunohistochemistry assays.
As an antimicrobial agent, polybia-MPII is highly effective, with a lower haemolysis rate compared to other mastoparans. Polybia-MPII also shows considerable anti-fungal activity.