Plectin-1–targeting peptide, AF488 labelled KTLLPTPGGSS-[Cys(AF488)]-acid
Description
Application Data
Description
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Plectin targeting peptide. Contains C-terminal Alexa fluor 488 green fluorescent dye
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1111336 Molecular Weight 1857.7 Sequence (one letter code) KTLLPTPGGSS-[Cys(AF488)]-acid Sequence (three letter code) H-Lys-Thr-Leu-Leu-Pro-Thr-Pro-Gly-Gly-Ser-Ser-[Cys(AF488)]-OH
Aliase PTP-Cys(AF488) Modifications Where AF488 is structurally identical to Alexa Fluor® 488 Purity >95% Storage -20°C References Bausch et al., (2009). Plectin-1 is a Biomarker of Malignant Pancreatic Intraductal Papillary Mucinous Neoplasms. J Gastrointest Surg. 13(11): 1948. PMID: 19760374
Osmanagic-Myers et al., (2015). Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks. J Cell Sci. 128(22): 4138. PMID: 26519478
Manufactured in: United Kingdom Plectin is a large protein found in nearly all mammalian cells and it acts as a link between the three main components of the cytoskeleton: actin microfilaments; microtubules and intermediate filaments. Plectin also links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. Therefore plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues.
In cardiac muscle and skeletal muscle, plectin is localised to specialised entities known as Z-discs. Plectin binds several proteins including: vinculin; DES; actin; fodrin; microtubule-associating proteins; nuclear laminin B; SPTAN1; vimentin and ITGB4. Mutations in PLEC have been associated with epidermolysis bullosa simplex with muscular dystrophy. Plectin has been proposed as a biomarker for pancreatic cancer.
Alexa Fluor 488 dye is a bright, green-fluorescent dye with excitation maxima around 490 and emission maxima around 525. Alexa Fluor 488 dye is pH-insensitive over a wide molar range.