Cyclic L27-11 TWLKKRRWKKAKpP

  • Description

  • Application Data

Description

Cyclic L27-11 is a potent antimicrobial molecule that targets the β-barrel outer membrane protein, LptD.  LptD plays an essential role in lipopolysaccharide transport to the outer membrane in Pseudomonas species.

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Application Data

Catalogue number crb1000753
Molecular Weight 1234.5
Sequence (one letter code) TWLKKRRWKKAKpP
Sequence (three letter code)

H-Thr-Trp-Leu-Lys-Lys-Arg-Arg-Trp-Lys-Lys-Ala-Lys-[D-Pro]-Pro-OH

Modifications where p is D-proline
Purity >95%
Storage -20°C
References

Schmidt et al., (2013). Structural studies of β-hairpin peptidomimetic antibiotics that target LptD in Pseudomonas sp. Bioorg Med Chem., 21(18): 5806. PMID: 23932450.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Cyclic L27-11 is a peptidomimetic compound that targets the outer membrane protein LptD. LptD is part of a complex that functions to transport lipopolysaccharides to the cell surface through the C-terminal β-barrel domain lumen, embedded within the outer membrane. Cyclic L27-11 can bind LptD and prevent translocation of lipopolysaccharides across the periplasm, even nanomolar doses were effective. This interaction gives cyclic L27-11 a potent antimicrobial activity particularly against the human pathogen Pseudomonas aeruginosa.

Modifications of cyclic L27-11 are under research to improve its stability for drug delivery. The peptide provided here has a D-proline substitution, characterised as have no antimicrobial activity against Pseudomonas aeruginosa

Cyclic L27-11

Cat No.Pack SizePriceQty.
0.5mg£170.00
1mg£220.00
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