Cyclic L27-11 TWLKKRRWKKAKpP
Cyclic L27-11 is a potent antimicrobial molecule that targets the β-barrel outer membrane protein, LptD. LptD plays an essential role in lipopolysaccharide transport to the outer membrane in Pseudomonas species.
Catalogue number crb1000753 Molecular Weight 1234.5 Sequence (one letter code) TWLKKRRWKKAKpP Sequence (three letter code)
Modifications where p is D-proline Purity >95% Storage -20°C References
Schmidt et al., (2013). Structural studies of β-hairpin peptidomimetic antibiotics that target LptD in Pseudomonas sp. Bioorg Med Chem., 21(18): 5806. PMID: 23932450.
Manufactured in: United Kingdom
Cyclic L27-11 is a peptidomimetic compound that targets the outer membrane protein LptD. LptD is part of a complex that functions to transport lipopolysaccharides to the cell surface through the C-terminal β-barrel domain lumen, embedded within the outer membrane. Cyclic L27-11 can bind LptD and prevent translocation of lipopolysaccharides across the periplasm, even nanomolar doses were effective. This interaction gives cyclic L27-11 a potent antimicrobial activity particularly against the human pathogen Pseudomonas aeruginosa.
Modifications of cyclic L27-11 are under research to improve its stability for drug delivery. The peptide provided here has a D-proline substitution, characterised as have no antimicrobial activity against Pseudomonas aeruginosa.