Pepstatin A Biotin

  • Description

  • Application Data

Description

Pepstatin A is a potent reversible inhibitor of aspartyly proteases such as pepsin and cathepsin D. This pepstain A peptide has a C-terminal biotin attached.

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Application Data

Catalogue number crb1001648
Molecular Weight 1041.7
Sequence (three letter code)

isovaleryl-Val-Val-Sta-Ala-Sta-PEG2-Biotin

Storage -20°C
Citations

Seelmeier et al., (1988). Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. PNAS., 85(18): 6612. DOI: 10.1073/pnas.85.18.6612.

References

Seelmeier et al., (1988). Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. PNAS., 85(18): 6612. DOI: 10.1073/pnas.85.18.6612.

Material Safety Data Sheet (MSDS)

Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy; this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments. Biotin is C-terminally linked to this peptide for convenient detection and purification. The polyethylene glycol (PEG) linker improves the water solubility of biotin labelled proteins. 

Pepstatin A Biotin

Cat No.Pack SizePriceQty.
£110.00
£85.00
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