Panx-1 mimetic inhibitory peptide WRQAAFVDSY-acid
Description
Application Data
Description
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Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages. It can also block activation of NMDA receptor secondary currents.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1001121 Molecular Weight 1241.6 Sequence (one letter code) WRQAAFVDSY-acid Sequence (three letter code) H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH
Aliase 10Panx Purity >95% cas 955091-53-9 Storage -20°C References Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor. EMBO J. 25 5071 PMID: 17036048
Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431
Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555 PMID: 19056988
Manufactured in: United Kingdom Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages. It can also block activation of NMDA receptor secondary currents.