Orexin A (OXA) fragment (17-33) is a potent and selective OX1 receptor agonist.
Catalogue number crb1000585 Molecular Weight 1747.9 Sequence (one letter code)
Sequence (three letter code)
Purity >95% Storage -20°C References
Grafe and Bhatnagar (2018). Orexins and stress. Front Neuroendocrinol. 51: 132. PMID: 29932958
Qiao et al., (2017). Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors. Invest Ophthalmol Vis Sci. 58(11): 4712. PMID: 28910447
Manufactured in: United Kingdom
Orexin-A (also known as hypocretin-1) is a hypothalamic neuropeptide that regulates feeding behaviour, reward processes, cognition, the sleep–wake cycle and stress. Orexin-A is involved in stress induced mental illness such as major depressive disorder and anxiety disorders and may therefore be a potential target for treatment of these conditions.
Orexins are excitatory neuropeptides generated from the prepro-orexin precursor that is exclusively localised in cells of the lateral and posterior hypothalamic region. Orexins are also widely expressed in human and mammalian retinas, such as bipolar cells, amacrine cells and ganglion cells.
Orexin-A activates the orphan G-protein–coupled orexin receptor, type 1 (OX1R) and 2 (OX2R). There are approximately 10,000–20,000 orexinergic neurons in the human brain.