Orexin A (monkey)
Orexin A is a neuropeptide involved in several processes, including feeding response, circadian rhythm, glucose metabolism and neuroendocrine functions.
Catalogue number crb1001105 Molecular Weight 3813 Sequence (one letter code)
Sequence (three letter code)
Aliase hypocretin Modifications disulphide bridge (Cys7-Cys13, Cys8-Cys15) Purity >95% cas 205640-90-0 Storage -20°C References
James et al., (2017). A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? Curr. Top. Behav. Neurosci., 33: 247. PMID: 28012090.
Nixon et al., (2015). Sleep disorders, obesity, and ageing: The role of orexin. Ageing Res. Rev., 20: 63. PMID: 25462194.
Wang et al., (2018). The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases. Front. Mol., Neurosci., 11. PMID: 30002617.
Manufactured in: United Kingdom
Orexin A is one of two closely related peptides; the orexins (also known as hypocretins). These small neuropeptides are secreted from orexin-containing neurons, located mainly in the lateral hypothalamus (LH). Orexins function via the binding and activation of two G-protein–coupled receptors (GPCRs); orexin receptor type 1 (OX1R) and 2 (OX2R).
Orexins play several vital roles in a range of physiological activities, including: circadian rhythm; feeding behaviour; energy balance; glucose metabolism; neuroendocrine functions; stress-adaptive responses and reward and addiction. Orexins have also been linked to the pathological processes of neurological diseases such as: narcolepsy; depression; ischemic stroke; drug addiction and Alzheimer’s disease.
This Orexin A peptide contains two disulphide bridges, one between cysteine 7 and cysteine 13, and the other between cysteine 8 and 15. Orexin-A appears to be the isoform most important for the feeding response.