Orexin A (monkey)

ARLLPDCCRQKTCPCRRYELLHRGGNHAGGLLVL-amide

  • Description

  • Application Data

Description

Orexin A is a neuropeptide involved in several processes, including feeding response, circadian rhythm, glucose metabolism and neuroendocrine functions.

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Application Data

Catalogue number crb1001105
Molecular Weight 3813
Sequence (one letter code)

ARLLPDCCRQKTCPCRRYELLHRGGNHAGGLLVL-amide

Sequence (three letter code)

H-Ala-Arg-Leu-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Pro-Cys-Arg-Arg-Tyr-Glu-Leu-Leu-His-Arg-Gly-Gly-Asn-His-Ala-Gly-Gly-Leu-Leu-Val-Leu-NH2

Aliase hypocretin
Modifications disulphide bridge (Cys7-Cys13, Cys8-Cys15)
Purity >95%
cas 205640-90-0
Storage -20°C
References

James et al., (2017). A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? Curr. Top. Behav. Neurosci., 33: 247. PMID: 28012090.

Nixon et al., (2015). Sleep disorders, obesity, and ageing: The role of orexin. Ageing Res. Rev., 20: 63. PMID: 25462194.

Wang et al., (2018). The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases. Front. Mol., Neurosci., 11. PMID: 30002617.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Orexin A is one of two closely related peptides; the orexins (also known as hypocretins). These small neuropeptides are secreted from orexin-containing neurons, located mainly in the lateral hypothalamus (LH). Orexins function via the binding and activation of two G-protein–coupled receptors (GPCRs); orexin receptor type 1 (OX1R) and 2 (OX2R).

Orexins play several vital roles in a range of physiological activities, including: circadian rhythm; feeding behaviour; energy balance; glucose metabolism; neuroendocrine functions; stress-adaptive responses and reward and addiction. Orexins have also been linked to the pathological processes of neurological diseases such as: narcolepsy; depression; ischemic stroke; drug addiction and Alzheimer’s disease.

This Orexin A peptide contains two disulphide bridges, one between cysteine 7 and cysteine 13, and the other between cysteine 8 and 15. Orexin-A appears to be the isoform most important for the feeding response.

Orexin A (monkey)

Cat No.Pack SizePriceQty.
0.5mg£110.00
1mg£220.00
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