Nociceptin
FGGFTGARKSARKLANQ-acid
Description
Application Data
Description
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Nociceptin is an endogenous ligand for the NOP opioid receptor. Administration of nociceptin leads to sensations of pain and is associated with memory, learning, and anxiety.
Application Data
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Data Sheet Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1001714 Molecular Weight 1808.0 Sequence (one letter code) FGGFTGARKSARKLANQ-acid
Sequence (three letter code) H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
Purity >95% References Li et al., (2022). Rostromedial tegmental nucleus nociceptin/orphanin FQ (N/OFQ) signaling regulates anxiety- and depression-like behaviors in alcohol withdrawn rats. Neuropsychopharmacol. doi: 10.1038/s41386-022-01482-3.
Manufactured in: United Kingdom Nociceptin is a potent anti-analgesic, effectively counteracting the effect of pain-relievers. A neuropeptide that modulates nociception, it acts by binding the nociceptin receptor (NOP). Nociceptin does not bind to μ, δ, or κ opioid receptors and thus lacks the addictive potential. Administration of nociceptin leads to sensations of pain and is associated with memory, learning, eating, and anxiety.
