Neuropeptide S human


  • Description

  • Application Data


Involved in several neuroendocrine, behavioural and inflammatory responses; including anxiety; suppressing appetite and inducing wakefulness and hyperactivity.

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Application Data

Catalogue number crb1000500
Molecular Weight 2186.1
Sequence (one letter code)


Sequence (three letter code)


Purity >95%
Storage -20°C

Acevedo et al (2017) Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma. PLOS ONE 12(5) e0176568 PMID: 28463995

Ionescu et al (2012) Intranasally Administered Neuropeptide S (NPS) Exerts Anxiolytic Effects Following Internalization Into NPS Receptor-Expressing Neurons. Neuropsychopharmacology 37(6) 1323 PMID: 22278093

Ren et al (2013) Neuropeptide S: a novel regulator of pain-related amygdala plasticity and behaviors. J. Neurophysiol. 110(8) 1765 PMID: 23883857

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Neuropeptide S (NPS) is a neuropeptide found in mammalian brains, primarily in neurons in the lateral parabrachial nucleus, the peri-locus coeruleus and the principle sensory 5 nucleus of the trigeminus. NPS in involved in several neuroendocrine, behavioural and inflammatory responses, including: reducing anxiety in mice; suppressing appetite and inducing wakefulness and hyperactivity. NPS treatment can be used to improve fear extinction in mice and limit fear memory retrieval after fear reduction training, thus making it an interesting target for treatment of post-traumatic stress disorder. NPS exerts its actions by binding to a G-protein coupled receptor, NPSR.

Neuropeptide S human

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