Neuromedin U 25

FRVDEEFQSPFASQSRGYFLFRPRN-amide

  • Description

  • Application Data

Description

Neuropeptide involved in cell signalling that mediates a plethora of physiological processes.

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Application Data

Catalogue number crb1001440
Molecular Weight 3078.5
Sequence (one letter code)

FRVDEEFQSPFASQSRGYFLFRPRN-amide

Sequence (three letter code)

H-Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2

Aliase human neuromedin U-25, NMU-25
Purity >95%
cas 312306-89-1
References

Gambone et al., (2011). The c-Myb target gene neuromedin U functions as a novel cofactor during the early stages of erythropoiesis. Blood117(21): 5733. PMID: 21378276

 

Moriyama et al., (2006). The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. Am J Physiol Lung Cell Mol Physiol. 290(5):L971-7. PMID: 16373672

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Neuromedin U (NmU) is a neuropeptide expressed in various organs including the brain, gut, bone marrow and lungs. NmU has a wide range of roles in physiology including: decreasing appetite and body weight and increasing gross locomotor activity, heat production, oxygen consumption, uterine smooth muscle contraction, body temperature, and bone mass. It is also involved in regulating circadian rhythm, stress response and blood flow and ion transport in the gut. NmU can also stimulate cytokine production and promote mast cell-mediated inflammation and is important during the early proliferative stages of erythroid development. NmU has been shown to be a c-Myb target gene and NmU in turn activates protein kinase C-βII, a factor associated with hematopoietic differentiation-proliferation.

Two related G protein–coupled receptors have been identified as NmU receptors: NMU-R1: expressed in various tissues, including the small intestine and lung, and NMU-R2: predominantly expressed in the hypothalamus and the small intestine. Activation of these receptors via NmU binding mobilises intracellular Ca2+ stores and downstream signalling.

Neuromedin U 25

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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