Mouse-ESC-derived cardiomyocyte-targeting peptide

  • Description

  • Application Data

Description

A phage displayed peptide found to specifically bind receptors on the surface membrane of mouse embryonic stem cell (ESC)-derived cardiomyocytes.

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Application Data

Catalogue number crb1001634
Molecular Weight 1314.7
Disease Area Cardiology
Sequence (three letter code)

H-Gln-Pro-Phe-Thr-Thr-Ser-Leu-Thr-Pro-Pro-Ala-Arg-OH

Storage -20°C
Citations

Cao et al., (2019). Bacteriophage-based biomaterials for tissue regeneration. Adv. Drug Deliv. Rev. 145: 73. https://doi.org/10.1016/j.addr.2018.11.004.

 

Li et al., (2011). The specific binding of peptide ligands to cardiomyocytes derived from mouse embryonic stem cells. Peptide Sci. 17(12): 771. https://doi.org/10.1002/psc.1401.

References

Cao et al., (2019). Bacteriophage-based biomaterials for tissue regeneration. Adv. Drug Deliv. Rev. 145: 73. https://doi.org/10.1016/j.addr.2018.11.004.

 

Li et al., (2011). The specific binding of peptide ligands to cardiomyocytes derived from mouse embryonic stem cells. Peptide Sci. 17(12): 771. https://doi.org/10.1002/psc.1401.

Material Safety Data Sheet (MSDS)

The progress of cardiovascular disease (CVD) comes from the damage and necrosis of cardiomyocytes. Although treatment has improved, once these cells are damaged, they cannot be recovered. Therefore, further research into cardiomyocytes is vital. Cardiomyocytes need to be in an exceedingly pure culture for research work. However, this requires identification of these cells from the ESCs present. With the use of a phage biopanning library, this sequence has been shown to have a high affinity to a receptor on the membrane surface of mouse ESC-derived cardiomyocytes. The functionality of this sequence allows it to be used a conjugate for drug or gene delivery to target cardiomyocytes or to purify cardiomyocytes in a research setting.

Mouse-ESC-derived cardiomyocyte-targeting peptide

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£110.00
£85.00
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