Melittin [Cy5]
GIGAVLKVLTTGLPALISWIKRKRQQ-[Cys(Sulfocyanine5)]-amide]
Description
Application Data
Description
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Melittin [Cy5] is comprised of the 26-residue peptide melittin, originally isolated from the venom of the European honeybee, and the Cy5 fluorescent Cy-Dye.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1130465 Molecular Weight 3712 Sequence (one letter code) GIGAVLKVLTTGLPALISWIKRKRQQ-[Cys(Sulfocyanine5)]-amide]
Sequence (three letter code) H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-[Cys(Sulfocyanine5)]-NH2
Purity >95% References Raghuraman and Chattopadhyay (2007) Melittin: a membrane-active peptide with diverse functions. Biosci Rep. (4-5) 189 PMID: 17139559
Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811. PMID: 9663445.
Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin. Differential inhibition of protein kinase C, Ca2+/calmodulin-dependent protein kinase II and synaptosomal membrane Na,K-ATPase, and Na+ pump and differentiation of HL60 cells.J. Biol. Chem. 266 2753. PMID: 1847132.
Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. Trends Pharmacol. Sci. 11 358. PMID: 2122563.
Ming-Tao Lee et al (2013) Process of inducing pores in membranes by melittin. PNAS 110 (35) 14243
Hall et al (2012) A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers. Nucleic Acids Res. 40 (14) e108 PMID: 22495935
Manufactured in: United Kingdom Melittin is a 26-residue cationic, haemolytic peptide isolated from honeybee venom. Melittin lowers the surface tension at the plasma membrane and causes cell lysis. It also exhibits potent anti-inflammatory and antimicrobial activity. Melittin has been extensively used as a model peptide for observing membrane lipid-protein interaction. In Melittin [Cy5] the fluorophore Cy5, a member of the Cy-Dye fluorescent molecule group which are most commonly used in DNA-related applications is added to the melittin peptide.