Melittin [Cy5]


  • Description

  • Application Data


Melittin [Cy5] is comprised of the 26-residue peptide melittin, originally isolated from the venom of the European honeybee, and the Cy5 fluorescent Cy-Dye.

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Application Data

Catalogue number crb1130465
Molecular Weight 3712
Sequence (one letter code)


Sequence (three letter code)


Purity >95%

Raghuraman and Chattopadhyay (2007) Melittin: a membrane-active peptide with diverse functions. Biosci Rep. (4-5) 189 PMID: 17139559

Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811. PMID: 9663445.

Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin. Differential inhibition of protein kinase C, Ca2+/calmodulin-dependent protein kinase II and synaptosomal membrane Na,K-ATPase, and Na+ pump and differentiation of HL60 cells.J. Biol. Chem. 266 2753. PMID: 1847132.

Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. Trends Pharmacol. Sci. 11 358. PMID: 2122563.

Ming-Tao Lee et al (2013) Process of inducing pores in membranes by melittin. PNAS 110 (35) 14243 

Hall et al (2012) A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers. Nucleic Acids Res. 40 (14) e108 PMID: 22495935

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Melittin is a 26-residue cationic, haemolytic peptide isolated from honeybee venom. Melittin lowers the surface tension at the plasma membrane and causes cell lysis. It also exhibits potent anti-inflammatory and antimicrobial activity. Melittin has been extensively used as a model peptide for observing membrane lipid-protein interaction. In Melittin [Cy5] the fluorophore Cy5, a member of the Cy-Dye fluorescent molecule group which are most commonly used in DNA-related applications is added to the melittin peptide.

Melittin [Cy5]

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