MBP Ac1-9 (4Y)

Ac-ASQYRPSQR-amide

  • Description

  • Application Data

Description

Acetylated N-terminal peptide of murine myelin basic protein (MBP). This peptide is a high MHC affinity variant with a lysine to tyrosine substitution at position 4

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Application Data

Catalogue number crb1000255
Molecular Weight 1133.22
Sequence (one letter code)

Ac-ASQYRPSQR-amide

Sequence (three letter code)

Ac-Ala-Ser-Gln-Tyr-Arg-Pro-Ser-Gln-Arg-NH2

Aliase Acetylated MBP Ac1-9 (4Tyr), MBP Ac1-9 (4Y), Myelin Basic Protein 1-9 (4Y), MBP1-9(4Y)
Purity >95%
References

Harauz and Boggs (2013) Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms. J. Neurochem. 125(3) 334 PMID: 23398367

 

Anderton et al (2001) Negative Selection during the Peripheral Immune Response to Antigen. J. Exp. Med. 193(1) 1 PMID: 11136816

 

CITATION: Saul et al (2019) 1,25-Dihydroxyvitamin D3 Restrains CD4+ T Cell Priming Ability of CD11c+ Dendritic Cells by Upregulating Expression of CD31. Front. Immunol. 10 doi:10.3389/fimmu.2019.00600

Data Sheet Material Safety Data Sheet (MSDS)

This peptide constitutes the acetylated N-terminal region of murine myelin basic protein (MBP) and displays high affinity for major histocompatibility complexes (MHC). This high MHC affinity is due to substitution of the native lysine at position 4 for a tyrosine. Substitution increases the MHC binding affinity of the peptide by around 1 million fold, therefore creating a superagonist ligand. MBP is an integral component of myelin found in the central nervous system (CNS) vital for the development and stability of the myelin sheath where it plays a role in membrane adhesion. MBP may be targeted by auto-antibodies in diseases such as multiple sclerosis. The low affinity of the native lysine containing MBP 1-9 peptide for MCH class II may result in MBP auto-reactive T cells escaping central-tolerance where self reactive T cells are usually eliminated. MBPs constitute an extraordinarily varied collection of splice isoforms which show a myriad of post-translational modifications.

MBP Ac1-9 (4Y)

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
25mg£750.00
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