Macropin 1 GFGMALKLLKKVL-amide

  • Description

  • Application Data


Anti-microbial peptide with activity against Gram-positive and Gram-negative bacteria, and fungi with low haemolytic activity.

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Application Data

Catalogue number crb1000053
Molecular Weight 1416.86
Sequence (one letter code) GFGMALKLLKKVL-amide
Sequence (three letter code)


Purity >95%
Storage - 20 ° C

Ko et al (2017) Macropis fulvipes Venom component Macropin Exerts its Antibacterial and Anti-Biofilm Properties by Damaging the Plasma Membranes of Drug Resistant Bacteria. Sci. Rep. 7(1) PMID: 29185466

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Macropin-1 (MAC-1) is an anti-microbial peptide (AMP) isolated from venom of the solitary bee Macropis fulvipes (Hymenoptera: Melittidae). MAC-1 has activity against both Gram-positive and Gram-negative bacteria, including drug-resistant strains. MAC-1 can inhibit biofilm formation in Staphylococcus aureus and Pseudomonas aeruginosa and also exhibits anti-fungal activity. MAC-1 has little to no haemolytic activity against human cells at microbiologically effective concentrations.

Macropin acts by first binding to negatively charged bacterial membrane components; such as peptidoglycan (PTG) or lipopolysaccharide (LPS). Macropin then kills the bacteria by disrupting the outer bacterial membrane and depolarising the cytoplasmic membrane to cause cell penetration

Macropin 1

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