Active fragment of the LL-37 peptide with anti-fungal properties
Catalogue number crb1000034 Molecular Weight 3043.57 Sequence (one letter code) IGKEFKRIVQRIKDFLRNLVPRTES-acid Sequence (three letter code) H-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-His-OH Molecular Weight 3043.57 Purity >95% Storage - 20 ° C References
Wong et al (2011) Antifungal action of human cathelicidin fragment (LL13–37) on Candida albicans. Peptides 32(10) 1996 PMID: 21889964
LL-13-37 is an active fragment of the LL-37 peptide which has been shown to have anti-fungal properties against Candida albicans.
LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37; this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also has anti-cancer properties and regulates many aspects of the innate immune system; overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis