Jak2 substrate GGEEEEYFELVKK-acid

  • Description

  • Application Data

Description

Phospho-substrate for JAK2 for use in kinase assays

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Application Data

Catalogue number crb1000270
Molecular Weight 1555.7
Sequence (one letter code) GGEEEEYFELVKK-acid
Purity >95%
Storage -20°C
References

Jay et al (2014) JAK2 Tyrosine Kinase Phosphorylates and Is Negatively Regulated by Centrosomal Protein Ninein. Mol. Cell Biol. 35(1) 111 PMID: 25332239

 

Liu et al (2017) Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction. Sci. Rep. 7(1) PMID: 28676638

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

This peptide is phosphorylated by Janus kinase 2 (JAK2) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.

JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.

Jak2 substrate

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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