Jak2 substrate GGEEEEYFELVKK-acid
Phospho-substrate for JAK2 for use in kinase assays
Catalogue number crb1000270 Molecular Weight 1555.7 Sequence (one letter code) GGEEEEYFELVKK-acid Purity >95% Storage -20°C References
Jay et al (2014) JAK2 Tyrosine Kinase Phosphorylates and Is Negatively Regulated by Centrosomal Protein Ninein. Mol. Cell Biol. 35(1) 111 PMID: 25332239
Liu et al (2017) Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction. Sci. Rep. 7(1) PMID: 28676638
Manufactured in: United Kingdom
This peptide is phosphorylated by Janus kinase 2 (JAK2) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.
JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.