JAG-1 (188-204) 1mg


  • Description

  • Application Data


Jagged – 1 is a cell surface ligand for in the Notch pathway. JAG-1(188-204)

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Application Data

Catalogue number crb1001588j
Molecular Weight 2105.9
Sequence (one letter code)


Sequence (three letter code)


Purity >95%
Storage -20°C

Grochowski et al., (2016). Jagged1 (JAG1): Structure, expression, and disease associations. Gene576(1 Pt 3): 381-4. PMID: 26548814


Pandya et al., (2016). PKCα Attenuates Jagged-1-mediated Notch Signaling in ErbB-2 positive Breast Cancer to Reverse Trastuzumab Resistance. Clin Cancer Res22(1): 175. PMID: 26350262

Manufactured in: United Kingdom
Material Safety Data Sheet (MSDS)

JAG-1(188-204). Jagged – 1 is a cell surface ligand for in the Notch pathway. Notch receptors and ligands are present on the extracellular service of cells and require cell-cell contact for engagement. Ligand binding to Notch receptors results in the proteolytic cleavage of membrane-bound Notch receptors, thus allowing the intercellular region to be transported to the nucleus and become a transcriptional activator. The ligand-induced Notch activation is regulated by E3 ubiquitin ligases, Mindbomb1 (Mib-1) and Neuralized.

JAG1 is widely expressed throughout mammalian development, across many tissues and developmental stages. Notch signalling plays a critical role in cellular fate determination including muscle cell differentiation, neurogenesis, and the development of the sensory regions of the inner ear; heart; kidney; eye; lung and other tissues.

Jag-1 has been implicated in breast; cervical; colorectal; endometrial; gastric; head and neck; ovarian; hepatocellular; lung; pancreatic; prostate, and kidney and adrenocortical cancers, leukemia and lymphoma. Co-overexpression of Notch-1 and Jagged-1 predicts the poorest overall cancer survival. JAG1 mutations have also been associated Alagille syndrome.

JAG-1 (188-204) 1mg

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