Insulin B (9-23)

SHLVEALYLVCGERG-acid

  • Description

  • Application Data

Description

This peptide is a short fragment of the insulin β chain (residues 9-23), and is recognised by pancreatic islet-associated T cells.

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Application Data

Catalogue number crb1001592
Molecular Weight 1644.8
Sequence (one letter code)

SHLVEALYLVCGERG-acid

Sequence (three letter code)

H-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-OH

Purity >95%
Storage -20°C
Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin β peptide may be a self-antigen candidate that could initiate the disease. Immunisation with this peptide in mice led to autoantibodies and insulitis. In the non-obese diabetic (NOD) mouse model, this peptide represents the dominant insulin peptide driving disease initiation.

Insulin is a polypeptide composed of two peptide chains referred to as the α chain and β chain. Insulin is normally secreted rapidly from the beta-cells of the pancreatic islets in response to nutrients absorbed after a meal. In type 1 diabetes mellitus, there may be an absolute insulin deficiency as a consequence of autoimmune destruction of the beta-cells.

Insulin B (9-23)

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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