Cathelicidin family anti-microbial peptide with broad killing spectrum, including Gram-positive and Gram-negative bacteria, fungi, protozoa and HIV
Catalogue number crb1000022 Molecular Weight 1906.28 Sequence (one letter code) ILPWKWPWWPWRR-amide Sequence (three letter code) H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2 Molecular Weight 1906.28 Purity >95% Storage - 20 ° C References
Sur et al (2015) Immune Activation Efficacy of Indolicidin Is Enhanced upon Conjugation with Carbon Nanotubes and Gold Nanoparticles. PLOS ONE 10(4) e0123905 PMID: 25876153
Pradhan et al (2017) Comparative efficacy analysis of anti-microbial peptides, LL-37 and indolicidin upon conjugation with CNT, in human monocytes. J. Nanobiotechnology 15(1) PMID: 28606090
Wiesner and Vilcinskas (2010) Antimicrobial peptides: The ancient arm of the human immune system. Virulence 1(5) 440 PMID: 21178486
Indolicidin is a natural cationic cathelicidin family anti-microbial peptide (AMP) with a very wide killing spectrum which includes: Gram-positive and Gram-negative bacteria, fungi, protozoa and HIV. It is also an immune system modulator and an inhibitor of aminoglycoside antibiotic resistance enzymes.
Indolicidin contains 5 tryptophan residues (39% of peptide content); the highest tryptophan proportion ever seen in a peptide or protein.
When indolicidin interacts with biological membranes it assumes a wedge- shaped conformation, with the hydrophobic tryptophan residues in the trough of the wedge, and positively charged regions flanking them at each end. If fully extended, indolicidin is able to span both lipid bilayers despite only consisting of 13 amino acid residues. This is possible because indolicidin adopts an approximate poly-l-proline type II helix conformation, which is characterized by very high helical pitches.
The exact mode of action of indolicidin is still unknown. At bactericidal concentrations the peptide appears to translocate through the membrane into the cytosol where it may bind to nucleic acids, whereas at higher concentrations it is membranolytic