IDR-1 (innate defence regulator) is an anti-infective peptide that acts to stimulate the innate immune response.
Catalogue number crb1000027 Molecular Weight 1391.74 Sequence (one letter code) KSRIVPAIPVSLL-amide Sequence (three letter code) H-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-NH2 Molecular Weight 1391.74 Purity >95% Storage - 20 ° C References M.G.Scott et al., Nat. Biotechnol., 25, 465 (2007)
As an antimicrobial peptide (AMP), IDR-1 acts indirectly on pathogenic bacterial infections. IDR-1 is proposed to function by upregulating monocyte cytokines (interleukins) while also reducing a pro-inflammatory cytokine. IDR-1 has been tested for its ability to aid against the rise of multi-drug resistant bacteria. In mouse models, IDR-1 is protective against Gram-positive and Gram-negative pathogens. Supply of IDR-1 can also attenuate methicillin-resistant staphylococcus aureus (MRSA)-induced pneumonia. The IDR-1 sequence is being studied as a template to hopefully generate more potent synthetic versions.