IDR-1 (innate defence regulator) is an anti-infective peptide that acts to stimulate the innate immune response.
Catalogue number crb1000027 Molecular Weight 1391.74 Sequence (one letter code) KSRIVPAIPVSLL-amide Sequence (three letter code)
Purity >95% Storage - 20 ° C References
Hou et al., (2013). Antimicrobial peptide LL-37 and IDR-1 ameliorate MRSA pneumonia in vivo. Cell Physiol Biochem., 32(3): 614. PMID: 24021961.
Levast et al., (2019). Synthetic cationic peptide IDR-1002 and human cathelicidin LL37 modulate the cell innate response but differentially impact PRRSV replication in vitro. Front. Vet. Sci., 6: 233. PMID: 31355218.
Manufactured in: United Kingdom
As an antimicrobial peptide (AMP), IDR-1 acts indirectly on pathogenic bacterial infections. IDR-1 is proposed to function by upregulating monocyte cytokines (interleukins) while also reducing a pro-inflammatory cytokine. IDR-1 has been tested for its ability to aid against the rise of multi-drug resistant bacteria. In mouse models, IDR-1 is protective against Gram-positive and Gram-negative pathogens. Supply of IDR-1 can also attenuate methicillin-resistant staphylococcus aureus (MRSA)-induced pneumonia. The IDR-1 sequence is being studied as a template to hopefully generate more potent synthetic versions.