HLA-A*02:01 NY-ESO-1 (157-165) SLLMWITQC-acid

  • Description

  • Application Data

Description

NY-ESO-1 peptide which is presented on MHC class I antigen HLA-A*02

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Application Data

Catalogue number crb1001034
Molecular Weight 1093.5
Sequence (one letter code) SLLMWITQC-acid
Sequence (three letter code)

H-Ser-Leu-Leu-Met-Trp-Ile-Thr-Gln-Cys-OH

Aliase CTAG1B
Purity >95%
Storage -20°C
References

Liu et al., (2019). Cancer stem-like cells with increased expression of NY-ESO-1 initiate breast cancer metastasis. Oncol Lett. 18(4): 3664. PMID: 31579408

 

Thomas et al., (2018). NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives. Front Immunol. 9: 947. PMID: 29770138

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

HLA-A*02 is a class I major histocompatibility complex (MHC) allele which is part of the HLA-A group of human major histocompatibility complex (MHC) leukocyte antigens (HLA). HLA-A is a human MHC class I cell surface receptor and is involved in presenting short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. Cytotoxic T cells in the blood “read” the peptide presented by the complex and should only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis.

New York oesophageal squamous cell carcinoma 1 (NY-ESO-1) is part of a well-characterized group of cancer/testis antigens (CTAs). Normally, NY-ESO-1 expression is restricted to germ cells and placental cells, however NY-ESO-1 is also expressed in several cancers including: neuroblastoma; myeloma; metastatic melanoma; synovial sarcoma as well as bladder; oesophageal; hepatocellular; head and neck; non-small cell lung; ovarian; prostate and breast cancers and is often associated with poor prognosis. NY-ESO-1 is also able to elicit a spontaneous immune response, being the most immunogenic among the CTA family members and is therefore the most promising CTA candidate target for cancer immunotherapy.

NY-ESO-1 is coexpressed with melanoma antigen gene C1, a member of the MAGE family of CTAs which is involved in cell cycle progression and apoptosis.

HLA-A*02:01 NY-ESO-1 (157-165)

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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