Histone H3-GGC-amide ARTKQTARKSTGGKAPRKQL-GGC-amide

  • Description

  • Application Data

Description

Histone protein H3 is a core component of the nucleosome, functioning in DNA compaction and availability to transcription machinery. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, “histone tail” which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. There is a wealth of data recording these modifications but understanding their significance is not as clear. The first 20 residues (1+20) of H3 N terminal domain are provided here. This sequence has already been used to investigate H3 phosphorylation and methylation events in the cell cycle. 

A glycine linker is C-terminally attached as a highly flexibly linker to allow the best pharmacokinetic profiling of the fused domain such as expression, localisation, or activity data. Provision of this H3 sequence with a glycine linker may allow further understanding of histone regulation.

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Application Data

Catalogue number crb1000318
Molecular Weight 2398.3
Sequence (one letter code) ARTKQTARKSTGGKAPRKQL-GGC-amide
Sequence (three letter code)

H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Gly-Gly-Cys-NH2

Aliase Abeta1-6
Purity >95%
References

Cowell et al., (2002). HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma, 111: 22. DOI: https://doi.org/10.1007/s00412-002-0182-8.

 

Hendzel et al., (1997). Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma, 106: 348. DOI: https://doi.org/10.1007/s004120050256. 

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Histone H3 peptide, a core histone protein of the nucleosome, with a C-terminal GGC linker.

Histone H3-GGC-amide

Cat No.Pack SizePriceQty.
1mg£110.00
0.5mg£85.00
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