Histone H3 (1-21)

  • Description

  • Application Data

Description

Histone H3 (1-21) is derived from Histone 3 (H3) which is one of the four core histones fundamental for compacting eukaryotic DNA into a structure known as the nucleosome.

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Application Data

Catalogue number crb1000617
Disease Area DNA damage, DNA modelling
Citations

Henneman et al., (2018) Structure and function of archaeal histones. PLOS. Genet., 14(9): e1007582. Doi: 10.1371/journal.pgen.1007582.

 

Hyland et al., (2005) Insights into the Role of Histone H3 and Histone H4 Core Modifiable Residues in Saccharomyces cerevisiae. Mol. Cell. Bio., (22): 10060. PMID: 16260619.

References

Henneman et al., (2018) Structure and function of archaeal histones. PLOS. Genet., 14(9): e1007582. Doi: 10.1371/journal.pgen.1007582.

 

Hyland et al., (2005) Insights into the Role of Histone H3 and Histone H4 Core Modifiable Residues in Saccharomyces cerevisiae. Mol. Cell. Bio., (22): 10060. PMID: 16260619.

Data Sheet Material Safety Data Sheet (MSDS)

Histone H3 (1-21) is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into a structure known as the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, “histone tail” which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.

Histone H3 (1-21) has been utilised in research as a substrate for methyltransferase (Histone 3 K4 and K9) and acetyltransferase (Histone 3 K9 and K14) assays. Histone H3 (1-21) and these assays have already provided vital insights into the role’s modifications play on the core histone functions. However, with so many histone modifications in different conditions still to be characterised the histone H3 (1-21) peptide still has a lot of insight to provide in the field.

Histone H3 (1-21)

Cat No.Pack SizePriceQty.
£85.00
£110.00
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