• Description

  • Application Data


A strong anticandidal and antibacterial peptide with protective effects inside the oral cavity.  

See full description

Application Data

Catalogue number crb1000016
Molecular Weight 3036.29
Sequence (one letter code) DSHAKRHHGYKRKFHEKHHSHRGY-acid
Sequence (three letter code) H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH
Molecular Weight 3036.29
Purity >95%
Storage - 20 ° C

Blotnick et al (2017) Interactions of histatin-3 and histatin-5 with actin. BMC Biochem. 18(1) PMID: 28264651

Data Sheet Material Safety Data Sheet (MSDS)

Histatins are histidine rich cationic peptides produced in salivary glands and released into the saliva. The main histatins that make up more than 80% of histatins in saliva are histatin 1, histatin 3 and histatin 5. There are two histatin genes, one which encodes histatin 1, and one that encodes histatin 3, all other histatins are derivatives of these two histatins. Histatin 3 is a precursor of histatin 5, each with distinct roles.

Histatin 5  is considered an antimicrobial peptide (AMP) as it has antibacterial activity as has been shown against opportunist infections such as P. aeruginosa, E. coli, and S. aureus. Histatin 5 also has potent anticandidal activity for example against Candida and Leishmania, it is shown to be the strongest antifungal of the histatins.  The antifungal activity functions by invasion of the microbe and entry to the mitochondria; histatin 5 then inhibits ATPase activity resulting in rapid depletion and ultimately bacterial cell death/apoptosis. As a salivary peptide, it inhibits Bacteroides gingivalis proteinase clostripain and protease activity a microbe implicated in periodontal disease.


Cat No.Pack SizePriceQty.
Bulk Quote