GPS1573

Nle-P-f-R-w-FKAVGKKRR-Lys(Nle-P-f-R-w-FKAVGKKRR-)-amide
Where lower case lettering denotes d-amino acids
Where Nle is norleucine

  • Description

  • Application Data

Description

GPS1573 is a potent and dose-dependent peptide antagonist of adrenocorticotrophic (ACTH) -stimulated melanocortin type 2 receptor (MC2R). The binding of ACTH to MC2R regulates steroidogenesis and can lead to metabolic diseases such as Cushing’s disease.

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Application Data

Catalogue number crb1000575
Molecular Weight 3685.3
Sequence (one letter code)

Nle-P-f-R-w-FKAVGKKRR-Lys(Nle-P-f-R-w-FKAVGKKRR-)-amide
Where lower case lettering denotes d-amino acids
Where Nle is norleucine

Sequence (three letter code)

H-nLeu-Pro-dPhe-Arg-dTrp-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-Lys(nLeu-Pro-dPhe-Arg-dTrp-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg)-OH

Purity >95%
Storage -20°C
References

Bouw et al (2014) Development of potent selective competitive-antagonists of the melanocortin type 2 receptor. Mol. cell. endocrinol. 394 99 PMID: 25017734

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

GPS1573 is a potent and dose-dependent peptide antagonist of adrenocorticotrophic (ACTH) -stimulated melanocortin type 2 receptor (MC2R). Along with GPS1574, GPS1773 is an ACTH analogue and as such antagonises MC2R in the nanomolar range.

The clinical relevance of GPS1573 is related to Cushing’s disease and syndrome, which are both associated with a hypercortisolemic state. Selective antagonism of MC2R using GPS1573 may be a novel treatment modality for Cushing’s disease and syndrome.

GPS1573

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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