GIP, human

YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ-acid

  • Description

  • Application Data

Description

Gastric inhibitory peptide (GIP) is a member of the secretin hormone family and plays an important role in the regulation of plasma glucose and insulin secretion.

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Application Data

Catalogue number crb1000991
Molecular Weight 4980.5
Sequence (one letter code)

YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ-acid

Sequence (three letter code)

H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH

Aliase Gastric inhibitory peptide
Purity >95%
cas 100040-31-1
Storage -20°C
References

Skrha et al (2010) Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients. Physiol. Res. 59(5) 749 PMID: 20406045

Yamada and Seino (2004) Physiology of GIP–a lesson from GIP receptor knockout mice. Horm. Metab. Res. 36 (11–12) 771 PMID: 15655707

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Gastric inhibitory polypeptide (GIP) is an inhibiting hormone of the secretin family of hormones. While GIP is a weak inhibitor of gastric acid secretion, its main role is to stimulate insulin secretion – in a glucose-dependent mechanism. Therefore, GIP is referred to as a glucose-dependent insulinotropic peptide.

GIP is derived from a 153-amino acid pro-protein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. It is synthesised by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal tract. GIP receptors are seven-transmembrane proteins found on beta-cells in the pancreas. These beta-cells are those that are able to simultaneously detect glucose and release insulin as a result to GIP binding.

The clinical relevance of GIP is related to type 2 diabetes mellitus (T2DM); studies have found that T2DM diabetics are unresponsive to GIP and have lower levels of GIP secretion after a meal when compared to non-diabetics. In research involving knockout mice, it was found that absence of the GIP receptors correlates with resistance to obesity.

GIP, human

Cat No.Pack SizePriceQty.
0.5mg£170.00
1mg£270.00
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