GIP (1-30) Human amide 0.5mg YAEGTFISDYSIAMDKIHQQDFVNWLLAQK-amide

£190.00
  • Description

  • Application Data

Description

Gastric inhibitory polypeptide (GIP) is an inhibiting hormone of the secretin family of hormones. While GIP is a weak inhibitor of gastric acid secretion, its main role is to stimulate insulin secretion – in a glucose-dependent mechanism. Therefore, GIP is referred to as a glucose-dependent insulinotropic peptide. GIP is derived from a 153-amino acid pro-protein… Read more »

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Application Data

Catalogue number crb1001473h
Molecular Weight 3529.7
Sequence (one letter code) YAEGTFISDYSIAMDKIHQQDFVNWLLAQK-amide
Sequence (three letter code)

H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2

Aliase GIP (1-30) Human
Purity >95%
Manufactured in: United Kingdom
Material Safety Data Sheet (MSDS)

Gastric inhibitory polypeptide (GIP) is an inhibiting hormone of the secretin family of hormones. While GIP is a weak inhibitor of gastric acid secretion, its main role is to stimulate insulin secretion – in a glucose-dependent mechanism. Therefore, GIP is referred to as a glucose-dependent insulinotropic peptide.
GIP is derived from a 153-amino acid pro-protein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. It is synthesised by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal tract. GIP receptors are seven-transmembrane proteins found on beta-cells in the pancreas. These beta-cells are those that are able to simultaneously detect glucose and release insulin as a result to GIP binding.
The clinical relevance of GIP is related to type 2 diabetes mellitus (T2DM); studies have found that T2DM diabetics are unresponsive to GIP and have lower levels of GIP secretion after a meal when compared to non-diabetics. In research involving knockout mice, it was found that absence of the GIP receptors correlates with resistance to obesity.

GIP (1-30) Human amide 0.5mg

0.5mg
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