Ghrelin-[Cys(AF647)] Human

GSSFLSPEHQRVQQRKESKKPPAKLQPR-[Cys(AF647)]-amide

  • Description

  • Application Data

Description

Ghrelin is an orexigenic hormone produced in the stomach, involved in stress response, immunity and glucose metabolism; a C-terminal structural analog to Alexa Fluor® 647 is attached.

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Application Data

Catalogue number crb1110382
Molecular Weight 4326.9
Sequence (one letter code)

GSSFLSPEHQRVQQRKESKKPPAKLQPR-[Cys(AF647)]-amide

Sequence (three letter code)

H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-[Cys(AF647)]-NH2

Purity >95%
References

Colldén et al., (2017). Therapeutic Potential of Targeting the Ghrelin Pathway. Int. J. Mol. Sci., 18(4): 798 PMID: 28398233.

Edwards and Abizaid, (2017). Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. Int. J. Mol. Sci., 18(4): 859 PMID: 28422060.

Pereira et al., (2017). The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective. J. Diabetes Res. PMID: 29082258.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Ghrelin is a peptide hormone mainly produced in the stomach. Ghrelin is involved in several physiological processes, including feeding, lipid accumulation, stress response; anxiety; cardiac performance; immunity and inflammation, taste sensation, reward-seeking behaviour, glucose metabolism and thermogenesis, memory, motivation and learning.

Ghrelin exerts its actions by binding the growth hormone secretagogue receptor (GHSR), mainly found in the hypothalamic and mesolimbic brain regions and peripheral organs (adipose tissue, adrenals, and stomach).

Ghrelin is produced by the cleavage of the precursor peptide preproghrelin. The attachment of a fatty acid to its serine 3 residue makes a form capable of activating GHSR.

Ghrelin is a valuable target for treating conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.

This ghrelin has a C-terminal AF647, a structural analog to Alexa Fluor® 647, a widely used far-red fluorescent dye. Its excitation is ideally suited to 594nm or 633nm. This dye is suited for low abundance targets as it has high initial brightness and a high photostability allowing detection of low abundance peptides. Cambridge Research Biochemicals is a custom peptide provider. If you desire an alternative dye, please contact us to request a custom synthesis.

Ghrelin-[Cys(AF647)] Human

Cat No.Pack SizePriceQty.
0.1mg£190.00
1mg£270.00
0.5mg£220.00
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