Feleucin-B01 was identified in the skin secretion of the toad Bombina orientalis and is shown to have weak antimicrobial activity against Gram-positive bacteria.
Catalogue number crb1000052 Molecular Weight 931.17 Sequence (one letter code) FLGLLGSLL-amide Sequence (three letter code) H-Phe-Leu-Gly-Leu-Leu-Gly-Ser-Leu-Leu-NH2 Molecular Weight 931.17 Purity >95% Storage - 20 ° C References Hou X et al Chem Biol Drug Des. 2015 Mar;85(3):259-67
Feleucin-B01 was recently identified from the skin secretion of the toad Bombina orientalis with a role in preventing the host from bacterial infection. Synthetic feleucin-B01 shows limited antimicrobial activity against a reference Gram-positive bacterium and is ineffective against the Gram-negative and yeast strains. The mode of action of the non-apeptide is lysis of the bacterial membrane resulting in rapid bacterial death. Feleucin-B01 shows a limited role in the secreted host defences which is complemented by the range of alternate antimicrobial peptides (AMP) also excreted. The amphipathic feleucin-B01 sequence is being studied as a template to hopefully generate more potent synthetic versions with a broader range of activity.