Feleucin-B01 FLGLLGSLL-amide

  • Description

  • Application Data


Feleucin-B01 was identified in the skin secretion of the toad Bombina orientalis and is shown to have weak antimicrobial activity against Gram-positive bacteria.

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Application Data

Catalogue number crb1000052
Molecular Weight 931.17
Sequence (one letter code) FLGLLGSLL-amide
Sequence (three letter code) H-Phe-Leu-Gly-Leu-Leu-Gly-Ser-Leu-Leu-NH2
Molecular Weight 931.17
Purity >95%
Storage - 20 ° C
References Hou X et al Chem Biol Drug Des. 2015 Mar;85(3):259-67
Data Sheet Material Safety Data Sheet (MSDS)

Feleucin-B01 was recently identified from the skin secretion of the toad Bombina orientalis with a role in preventing the host from bacterial infection. Synthetic feleucin-B01 shows limited antimicrobial activity against a reference Gram-positive bacterium and is ineffective against the Gram-negative and yeast strains. The mode of action of the non-apeptide is lysis of the bacterial membrane resulting in rapid bacterial death. Feleucin-B01 shows a limited role in the secreted host defences which is complemented by the range of alternate antimicrobial peptides (AMP) also excreted. The amphipathic feleucin-B01 sequence is being studied as a template to hopefully generate more potent synthetic versions with a broader range of activity. 


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