Feleucin-B01 FLGLLGSLL-amide
Description
Application Data
Description
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Feleucin-B01 was identified in the skin secretion of the toad Bombina orientalis and is shown to have weak antimicrobial activity against Gram-positive bacteria.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000052 Molecular Weight 931.17 Sequence (one letter code) FLGLLGSLL-amide Sequence (three letter code) H-Phe-Leu-Gly-Leu-Leu-Gly-Ser-Leu-Leu-NH2
Purity >95% Storage - 20 ° C References Hou et al., (2015). Feleucin-BO1: a novel antimicrobial non-apeptide amide from the skin secretion of the toad, Bombina orientalis, and design of a potent broad-spectrum synthetic analogue, feleucin-K3. Chem Biol Drug Des., 85(3) :259. PMID: 25056849.
Manufactured in: United Kingdom Feleucin-B01 was recently identified from the skin secretion of the toad Bombina orientalis with a role in preventing the host from bacterial infection. Synthetic feleucin-B01 shows limited antimicrobial activity against a reference Gram-positive bacterium and is ineffective against the Gram-negative and yeast strains. The mode of action of the non-apeptide is lysis of the bacterial membrane resulting in rapid bacterial death. Feleucin-B01 shows a limited role in the secreted host defences which is complemented by the range of alternate antimicrobial peptides (AMP) also excreted. The amphipathic feleucin-B01 sequence is being studied as a template to hopefully generate more potent synthetic versions with a broader range of activity.