Exendin 3 is a potent and selective glucagon-like peptide-1 receptor (GLP-1R) antagonist.
Catalogue number crb1000147 Molecular Weight 4202.63 Sequence (one letter code)
Sequence (three letter code)
Purity >95% cas 130357-25-4 Storage This material should be stored below 0 degrees C References
Raufman et al., (1991). Exendin-3, a novel peptide from the Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. J.Biol.Chem., 266: 2897. PMID: 1704369.
Turton et al., (1996). A role for glucagon-like peptide-1 in the central regulation of feeding. Nature, 379: 69. PMID: 8538742.
Originally identified in Heloderma horridum horridum (Mexican beaded lizard), exendin-3 is in the glucagon family. Exendin 3 stimulates vasoactive intestinal peptide (VIP) receptors in high concentrations. This leads to increased cAMP levels and amylase secretion in the pancreas. However, low exendin-3 exposure only increases cAMP levels.
In applications, exendin-3 was found to induce hypotension by relaxation of cardiac, smooth muscle. Using a tag, exendin-3 is being investigated as a stable agonist for GLP1R to detect insulinomas, a pancreatic B cell-derived cancer with high GLP1R expression. Exendin 3 has also been used on mouse models to assess its effect on glucose-stimulated insulin secretion in glucagon receptor knockout (Gcgr-/-) backgrounds. Understanding the interplay between exendin 3 and metabolism could provide new insights into the obesity crisis.
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