epsilon – PKC Inhibitor EAVSLKPTC-acid
Selective εPKC antagonist with C-terminal cysteine residue for conjugation to carrier proteins
Catalogue number crb1001138 Molecular Weight 946.5 Sequence (one letter code) EAVSLKPTC-acid Sequence (three letter code)
Purity >95% Storage -20°C References
Brandman et al (2007) Peptides Derived from the C2 Domain of Protein Kinase C (PKC) Modulate PKC Activity and Identify Potential Protein-Protein Interaction Surfaces. J. Biol. Chem. 282(6) 4113 PMID: 17142835
Manufactured in: United Kingdom
eV1–2 is a selective εPKC inhibitor peptide which interferes with protein-protein interactions between the ϵPKC isozyme and its anchoring protein (ϵRACK). ϵPKC and ϵRACK regulate the contraction rate of heart muscle cells and provide protection from ischemia induced cell death. ϵV1-2 is derived from the C2 domain of ϵPKC, a region important for protein-protein interactions and thus acts as a competitive inhibitor of these interactions.
The C2 region is well conserved between species, but different enough from other PKC isozymes to allow for targeted inhibition (ϵV1-2 is 88% identical between sea slugs and rat ϵPKC, yet only 36% identical between rat ϵPKC and rat δPKC).
This peptide contains a C-terminal cysteine residue for conjugation to a carrier protein.