(Des-octanoyl)-Ghrelin Human

GSSFLSPEHQRVQQRKESKKPPAKLQPR-acid

  • Description

  • Application Data

Description

Most circulating ghrelin is in this modified form (des-octanoyl) ghrelin. Unlike ghrelin, it does not stimulate growth hormone release or bind the ghrelin receptor (GHS-R1a).

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Application Data

Catalogue number crb1000388
Molecular Weight 3242.8
Sequence (one letter code)

GSSFLSPEHQRVQQRKESKKPPAKLQPR-acid

Sequence (three letter code)

H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH

Aliase Des-Acyl Ghrelin, DAG, Desacyl Ghrelin
Purity >95%
cas 313951-59-6
References

Lear et al., (2010). Des-Acyl Ghrelin Has Specific Binding Sites and Different Metabolic Effects from Ghrelin in Cardiomyocytes. Endocrinology, Volume 151 (7): 3286. doi: 10.1210/en.2009-1205.

Delhanty et al., (2014). Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do?. Front Horm Res., 42: 163. doi: 10.1159/000358345.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Ghrelin is an orexigenic peptide hormone mainly produced in the stomach as precursor preproghrelin. Cleavage of preproghrelin followed by modification leads to the formation of ghrelin with the addition of a fatty acid to its serine 3 residue; ghrelin is capable of activating the growth hormone release receptor (GHSR). Ghrelin is involved in appetite stimulation and growth hormone release.

Most circulating ghrelin is in the non-acylated form (des-octanoyl) ghrelin. (Des-octanoyl)-ghrelin has some distinct functions from ghrelin, the lack of acylation prevents binding to the ghrelin receptor and growth hormone release. However, (des-octanoyl) ghrelin has negative inotropic effects on papillary muscle and cardioprotective function. There is evidence (des-octanoyl) ghrelin inhibits proliferation of certain cancer cell lines, while promoting adipogenesis has been observed in other experiments in vivo.

(Des-octanoyl)-Ghrelin Human

Cat No.Pack SizePriceQty.
1mg£110.00
0.5mg£85.00
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