[Des-Arg9]-Bradykinin Heavy RPPG-[U-13C9,15N-Phe]-SPF-acid
Description
Application Data
Description
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Potent and highly selective bradykinin B(1) receptor agonist with hypotensive activities. The phenylalanine at position 5 of this peptide is isotopically labelled with Carbon-13 (9) and Nitrogen-15 (1).
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1300683 Molecular Weight 913.5 Sequence (one letter code) RPPG-[U-13C9,15N-Phe]-SPF-acid Sequence (three letter code) "H-Arg-Pro-Pro-Gly-[U-13C9,15N-Phe]-Ser-Pro-Phe-OH " Purity >95% Storage -20°C References Leeb-Lundberg (2005) International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences. Pharmacol. Rev. 57(1) 27 PMID: 15734727
Seliga et al (2018) Kallikrein–Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation. Front. Immunol. 9 156 PMID: 29456540
Manufactured in: United Kingdom [Des-Arg9]-Bradykinin Heavy is a metabolite of des-Arg(9)kinin and its production is increased upon inflammation. [Des-Arg9]-Bradykinin Heavy acts on the bradykinin B(1) receptor as a potent and highly selective receptor agonist.
The bradykinin receptor B1Rs is a heterotrimeric G-protein coupled receptor which regulates migration of microglia and T cells. The expression of the B(1) receptor is induced in various inflammatory conditions, and may play an important role in modulating cardiovascular function.
The phenylalanine residue at position 5 of this peptide is isotopically labelled with Carbon-13 (9) and Nitrogen-15 (1).